Case It v5.03 is a computer simulation that will perform common laboratory procedures on any DNA or protein sequence, including PCR, ELISA, DNA gel electrophoresis, western blot, Southern blot and so on. By using the computer simulation together with designed cases (such as infectious diseases, inherited diseases or crime scenes), students will have the opportunities to propose questions, construct hypothesis, design experiments, and carry out experiments with the computer simulation lab. To use the computer simulation, one has to download the software Case It v5.03 from this webpage http://caseit.uwrf.edu//tutorialv5/download2.html The cases are constructed within another software, Investigator v2.0, from the same webpage http://caseit.uwrf.edu//tutorialv5/download2.html. Investigator v.2.0 contains the case descriptions (like lesson plans) that help instructors design lessons. Instructors can also find abundant resources in Investigator v.2.0. This webpage shows the video case of HIV http://caseit.uwrf.edu//tutorialv5/invest/tutor3b.html The powerpoints may help you understand the rationale of CaseIt and get familar with the interface http://caseit.uwrf.edu//powerpoint.htm NOTES: To explore the software, I tried HIV case study. I first opened Investigator v2.0 for case descriptions and video cases. HIV case descriptions were found under case information, then under infectious diseases. I printed the instructions out so I didn't need to switch between Investigator v2.0 and Case It v.5.03. When first playing with the lab simulation (Case It v.5.03), I found the online tutorials very helpful because they have screen captures. http://caseit.uwrf.edu//tutorialv5/Protein/1.htm Playing with the software is like doing real wet lab. Without careful design, experiments will fail or you will get unexpected results.