This activity is designed to help students with the concepts of mitosis and meiosis. Specifically, the activity is designed to help students learn the different recognized stages of mitosis, differentiate homologous and nonhomologous chromosomes and recognize sister chromatids (duplicated chromosomes). In addition, students complete an activity in which they simulate/model the process of meiosis, while comparing and contrasting the outcomes of mitosis and meiosis. A variety of instructional techniques are employed, including video, lecture, active group work, and questioning. The activity is designed to work for any class size, and is applicable to both majors and non-majors courses in introductory biology. The activities may work best in a recitation setting, though slight modifications could facilitate its application in a large lecture setting.