In this approximately 20 to 25 minute lecture activity, students work collaboratively in groups to learn about the genetic basis of, and molecular mechanisms behind, the variation observed in squirrel coat color. As components of the activity, students will respond in groups to clicker style questions, and will work together to complete a worksheet that, ultimately, requires the construction of a model to represent the gene-to-phenotype sequence that results in the coat color variation observed in a population.